|
KMID : 0378019660090060101
|
|
New Medical Journal
1966 Volume.9 No. 6 p.101 ~ p.118
|
|
|
Experimental studies on the effects of Streptomycin Sulfate upon the tissue mast cells on the skin and various tissues in Albino Rats
|
|
|
|
|
Abstract
|
|
|
Observations on the appearance of the tissue mast cells in the trachea, the esophagus, the stomach and the skin were made after intramuscular injection of 2.0, 30.0 and 60.0 mg./c.c. of streptomycin sulfate per 100 gm of body weight respectively, on the central portion of the lateral side of the right thigh with 22 gauge needle with follow-ups after various time intervals, using healthy albino-rats weighing 120-430 gm. each. The results were as follows:
1. The tissue mast cells of the trachea, the esophagus, the stomach and the skin decreased numerically to minimum at about 3 hrs. after the intramuscular injection of streptomycin sulfate, 2.0 and 30 mg. per 100 gm. of body wight, respectively. The change was somewhat rapid in the skin of the contralateral side of the injection. After the injection of 60 mg. of streptomycin sulfate per 100 gm. of body weight, the time to reach the minimum was 4 hrs. and the decrease was more marked.
2. In the experimental group of the intramuscular injection of 2.0 and 30 mg. of streptomycin sulfate per 100 gm. of body weight, respectively, the numerical change of the tissue mast cells was almost same and recovery to the normal value achieved at 8 hrs. after injection in the trachea, the esophagus and the stomach, and at 12 hrs. in the skin. Thereafter, no significant change was noted.
3. The time of recovery to not wal from the minimum in the number of tissue mast cells tended to increase with the degree of decrease in the number of the tissue mast cells and was most delayed in the group of the 60 mg. per 100 gm. of body weight doses of streptomycin sulfate, in which the normal value was reached after 12 hrs. in the trachea, the esophagus and the stomach, and 48 hrs. in the skin, showing only slight fluctuations thereafter.
4. The decrease of the tissue mast cells was more mild in the esophagus and the stomach and more severe in the trachea and the skin with all of the dosages given.
5. The numerical changes in the tissue mast cells of the contralateral side of the injection was almost same as in the skin of the injected side.
6. In the morphology of the tissue mast cells after stimulations with various dosages, the percentage of the normal mast cells decreased and that of the degranulating form of the tissue mast cells increased with the decrease in the number of the tissue mast cells and thereafter, as the number of the mast cells increased, the percentage of the normal form increased and that of the degranulating form decreased, thus reaching the normal state. In general, the more the dosage of drug, the more delay in the time of recovery in the percentage of the normal form than in the number of the mast cells.
7. It is interpreted that the changes of the tissue mast cells of various organs by the intramuscular injection of streptomycin sulfate not only due to the reaction to the drug and/or the injection but also a manifestation of a systemic, non-specific reaction.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|